alpha 1 microglobulin wiki

... החלבון α-1-microglobulin (להלן α1M) התגלה בשתן על ידי הקבוצה השוודית של Berggard בשנת 1975 במאמר שהתפרסם ב-Biochem Biophys Res Commun. Das Protein wird vorwiegend in der Leber synthetisiert. "Beta gene 2-microglobulina è mutato in una linea di cellule di cancro del colon umano (HCT) carenti di espressione di HLA di classe I antigeni sulla superficie delle cellule". Unlike α 3, β 2 has no transmembrane region. AMBP (англ. 2. Just better.

Acta, vol.

Examples include: Beta-2 microglobulin; Alpha-1-microglobulin This is caused by an array of small chromophore prosthetic groups, attached to amino acid residues at the entrance of the lipocalin pocket. It can be contrasted to macroglobulin., . Fig. Die Funktion des Proteins besteht u. a. in der Bindung und dem Abbau der Häm-Komponente des Hämoglobins. Es wird auch als Protein HC bezeichnet.. Eigenschaften. Peterson, I. Berggård "A urinary and plasma alpha-1-glycoprotein of low molecular weight: isolation and some properties." α2纤溶酶抑制剂 （ 英语 ： Alpha 2-antiplasmin ） 抗凝血酶 （ 英语 ： Antithrombin ） 肝素辅因子II （ 英语 ： Heparin cofactor II ） A cysteine residue on one of the loops at the open end of the basket is of central importance for the function.

alpha(1)-Microglobulin, also called protein HC, is a lipocalin with immunosuppressive properties. Biochemical characterization and comparison with alpha 1-microglobulin synthesized by human hepatocytes.Purification of alpha 1-microglobulin produced by human hepatoma cell lines. It belongs to a protein family, the lipocalins, all members of which are shaped as a basket built from eight beta-strands of the peptide chain. Europe PubMed Central. Statements. The gene is translated into the alpha(1)-microglobulin-bikunin precursor, which is subsequently cleaved and the two proteins secreted to the blood separately. PMID 1.737.380. It belongs to a protein family, the A1M is also immunoregulatory: the immune response of lymphocytes and neutrophils is partly suppressed by A1M.A1M is a candidate for a number of therapeutic applications which includes the treatment or alleviation of preeclampsia, tissue damage caused by bleeding in brain, and chronic leg ulcers.B. Human A1M is composed of a 183-amino-acid peptide carrying three carbohydrate chains. Alpha-1-microglobulin/bikunin precursor) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 9-ї хромосоми. The protein has been found in a number of vertebrate species including frogs and fish.

It is most abundant at interfaces between the cells of the body and the environment, such as in lungs, intestine, kidneys and placenta. Alpha 1-microglobulin has commonly been substituted for [[beta].sub.2]-microglobulin as a marker for tubular proteinuria as the latter is sensitive to pH changes whereas the former is not (11).

Diseases associated with AMBP include Hepatitis E and Pyelonephritis.Among its related pathways are Cell adhesion_Cell-matrix glycoconjugates and Binding and Uptake of Ligands by Scavenger Receptors.Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and serine-type … Cartoon representation of a three-dimensional model of α1m. PubMed ID. Cancer Res.

אלפא-1 מיקרוגלובולין - Alpha-1-microglobulin. α1胰凝乳蛋白酶抑制剂 （ 英语 ： Alpha 1-antichymotrypsin ） α1-抗胰蛋白酶 （ 英语 ： Alpha-1 antitrypsin ） α2. Instructions on how to enable JavaScript on different browsers can be found here: Ideally this entry shall become one comprehensive and continuous article. Tubulopathien) eine Rolle spielt. Saper MA, Bjorkman PJ, Wiley DC (1991). Purification of alpha 1-microglobulin produced by human hepatoma cell lines. Gattoni-Celli S, Kirsch K, R Timpane, Isselbacher KJ (1992). stated in. 11699 Ensembl ENSG00000106927 ENSMUSG00000028356 UniProt P02760 Q07456 RefSeq (mRNA) NM_001633 NM_007443 RefSeq (protein) NP_001624 NP_031469 Location (UCSC) Chr 9: 114.06 – 114.08 Mb Chr 4: 63.14 – 63.15 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein AMBP is a protein that in humans is encoded by the AMBP gene. Microglobulin is a globulin of relatively small molecular weight. (1) It is synthesized in the liver, freely filtered by glomeruli, and reabsorbed by renal proximal tubules cells where it is catabolized. Nephrotoxicity of cadmium & lead The figure is modified from [18]. This review summarizes the present knowledge of its structure, biosynthesis, tissue distribution and immunoregulatory properties. Identifiers, A1M, EDC1, HCP, HI30, IATIL, ITI, ITIL, ITILC, UTI, alpha-1-microglobulin/bikunin precursor: External IDs alpha(1)-Microglobulin has a yellow-brown color and is size and charge heterogeneous. אלפא-1 מיקרוגלובולין - Alpha-1-microglobulin. Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.Hoffmann, R. A wiki for the life sciences where authorship matters. The protein has been found in a number of vertebrate species including frogs and fish. Biophys. Довжина поліпептидного ланцюга білка становить 352 амінокислот, а молекулярна маса — 38 999. Purification of alpha 1-microglobulin produced by human hepatoma cell lines. RA1M : Alpha-1-microglobulin is a low-molecular-weight protein of 26 kDa and a member of the lipocalin protein superfamily. PMID 1.448.153.

2439335. The genes for aldolase-B , the alpha 1-microglobulin/bikunin precursor , the paired box gene PAX5, and the anonymous DNA marker D9S3 map to human chromosome 9 (HSA9) .

Bulleted lists, for instance, were only used because it is impossible to automatically integrate independent facts into a continuous text.Much of the current information on this page has been automatically compiled from Pubmed.This precompiled information serves as a substrate and matrix to embed your contributions, but it is by no means the final word - Human A1M is composed of a 183-amino-acid peptide carrying three carbohydrate chains. 1 reference. Contents 1 Interactions 2 See also 3 …

It is synthesized in most cells of the body, but mainly in the liver from a gene that codes for the alpha-1-microglobulin/bikunin precursor.

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